Active targeting with particulate carrier systems in the blood compartment
Identifieur interne : 002B22 ( Main/Exploration ); précédent : 002B21; suivant : 002B23Active targeting with particulate carrier systems in the blood compartment
Auteurs : D. J. A. Crommelin [Pays-Bas] ; G. Scherphof [Pays-Bas] ; G. Storm [Pays-Bas]Source :
- Advanced Drug Delivery Reviews [ 0169-409X ] ; 1995.
English descriptors
- Teeft :
- Adhesion, Adhesion molecules, Albumin microspheres, Antibody, Artificial embolus formation, Basic characteristics, Blood cells, Blood circulation, Blood compartment, Boca raton, Carrier, Carrier system, Carrier systems, Cationic liposomes, Chloroquineladen liposomes, Circulation times, Complex formation, Crommelin, Drug delivery, Drug delivery reviews, Drug molecules, Drug release, Drug therapy, Elsevier science publ, Endothelium, First capillary, Gene therapy, Hand side, Homing, Homing device, Homing devices, Huang, Immunoliposomes, Inflammation sites, Interesting concept, Intravenous, Intravenous injection, Intravenous route, Large number, Lesa technique, Liposome, Local drug release, Local hyperthermia, Localization, Long circulation times, Lung accumulation, Macrophage, Magnetic field gradients, Medical aspects, Microspheres, Molecule, Mouse lung, Multidisciplinary approach, Multivalent interactions, Particle size, Particulate, Particulate carrier systems, Particulate carriers, Particulate systems, Pathological conditions, Pathological considerations, Physical strategies, Polyethylene glycol, Practical considerations, Recent review, Review deals, Right hand side, Same group, Solid tumours, Target cell, Target cells, Target organ, Target site, Target sites, Therapeutic advantage, Therapeutic effect, Tumour, Vascular system, Vivo.
Abstract
Abstract: This review deals with active targeting of particulate drug carriers through (1) physico-chemical (e.g., complex formation between a homing device and a surface exposed molecule at the target site) and (2) physical means. Target sites discussed are restricted to those in the blood circulation. Targets for particulate systems using homing devices (physico-chemical approach) are circulating cells and non-cellular material, e.g., red blood cells, T-lymphocytes, B-lymphocytes, and drugs, respectively. Fixed cells and non-cellular material have also been subject of investigation (e.g., endothelial cells and thrombi, respectively). Active targeting in the above areas has been mainly performed with liposomes as carrier systems and monoclonal antibodies or antibody fragments as homing devices. Less literature is available on physical targeting approaches in the blood compartment such as targeting through magnetic field gradients, local hyperthermia or artificial embolus formation.
Url:
DOI: 10.1016/0169-409X(95)00040-E
Affiliations:
- Pays-Bas
- Groningue (province), Utrecht (province)
- Groningue (ville), Utrecht
- Université d'Utrecht, Université de Groningue
Links toward previous steps (curation, corpus...)
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- to stream Istex, to step Curation: 001591
- to stream Istex, to step Checkpoint: 001913
- to stream Main, to step Merge: 002B80
- to stream Main, to step Curation: 002B22
Le document en format XML
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Storm</name><affiliation wicri:level="4"><orgName type="university">Université d'Utrecht</orgName><country>Pays-Bas</country><placeName><settlement type="city">Utrecht</settlement><region nuts="2">Utrecht (province)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Advanced Drug Delivery Reviews</title><title level="j" type="abbrev">ADR</title><idno type="ISSN">0169-409X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="49">49</biblScope><biblScope unit="page" to="60">60</biblScope></imprint><idno type="ISSN">0169-409X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0169-409X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adhesion</term><term>Adhesion molecules</term><term>Albumin microspheres</term><term>Antibody</term><term>Artificial embolus formation</term><term>Basic characteristics</term><term>Blood cells</term><term>Blood circulation</term><term>Blood compartment</term><term>Boca raton</term><term>Carrier</term><term>Carrier system</term><term>Carrier systems</term><term>Cationic liposomes</term><term>Chloroquineladen liposomes</term><term>Circulation times</term><term>Complex formation</term><term>Crommelin</term><term>Drug delivery</term><term>Drug delivery reviews</term><term>Drug molecules</term><term>Drug release</term><term>Drug therapy</term><term>Elsevier science publ</term><term>Endothelium</term><term>First capillary</term><term>Gene therapy</term><term>Hand side</term><term>Homing</term><term>Homing device</term><term>Homing devices</term><term>Huang</term><term>Immunoliposomes</term><term>Inflammation sites</term><term>Interesting concept</term><term>Intravenous</term><term>Intravenous injection</term><term>Intravenous route</term><term>Large number</term><term>Lesa technique</term><term>Liposome</term><term>Local drug release</term><term>Local hyperthermia</term><term>Localization</term><term>Long circulation times</term><term>Lung accumulation</term><term>Macrophage</term><term>Magnetic field gradients</term><term>Medical aspects</term><term>Microspheres</term><term>Molecule</term><term>Mouse lung</term><term>Multidisciplinary approach</term><term>Multivalent interactions</term><term>Particle size</term><term>Particulate</term><term>Particulate carrier systems</term><term>Particulate carriers</term><term>Particulate systems</term><term>Pathological conditions</term><term>Pathological considerations</term><term>Physical strategies</term><term>Polyethylene glycol</term><term>Practical considerations</term><term>Recent review</term><term>Review deals</term><term>Right hand side</term><term>Same group</term><term>Solid tumours</term><term>Target cell</term><term>Target cells</term><term>Target organ</term><term>Target site</term><term>Target sites</term><term>Therapeutic advantage</term><term>Therapeutic effect</term><term>Tumour</term><term>Vascular system</term><term>Vivo</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: This review deals with active targeting of particulate drug carriers through (1) physico-chemical (e.g., complex formation between a homing device and a surface exposed molecule at the target site) and (2) physical means. Target sites discussed are restricted to those in the blood circulation. Targets for particulate systems using homing devices (physico-chemical approach) are circulating cells and non-cellular material, e.g., red blood cells, T-lymphocytes, B-lymphocytes, and drugs, respectively. Fixed cells and non-cellular material have also been subject of investigation (e.g., endothelial cells and thrombi, respectively). Active targeting in the above areas has been mainly performed with liposomes as carrier systems and monoclonal antibodies or antibody fragments as homing devices. Less literature is available on physical targeting approaches in the blood compartment such as targeting through magnetic field gradients, local hyperthermia or artificial embolus formation.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Groningue (province)</li><li>Utrecht (province)</li></region><settlement><li>Groningue (ville)</li><li>Utrecht</li></settlement><orgName><li>Université d'Utrecht</li><li>Université de Groningue</li></orgName></list><tree><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Crommelin, D J A" sort="Crommelin, D J A" uniqKey="Crommelin D" first="D. J. A." last="Crommelin">D. J. A. Crommelin</name></region><name sortKey="Scherphof, G" sort="Scherphof, G" uniqKey="Scherphof G" first="G." last="Scherphof">G. Scherphof</name><name sortKey="Storm, G" sort="Storm, G" uniqKey="Storm G" first="G." last="Storm">G. 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